What is UPLC? UPLC is the result of holistic innovation that simultaneously re-engineered LC particle technology, column design, injectors, pumps, and detectors. The increased performance of sub-2-μm hybrid columns, used in conjunction with the ACQUITY UPLC^® System's specialized ability to deliver mobile phase at high pressures with low dispersion, preserves the chromatographic benefits of such small-particle chemistries — producing sharper and more concentrated peaks. ACQUITY UPLC increases your throughput and reduces solvent use without compromising analytical results.